Our sensors in human disease

VOCs for human disease: Fighting antimicrobial resistance

Antimicrobial resistance (AMR) is a growing public health concern that is caused by the overuse and misuse of antibiotics. One of the major drivers of AMR is the inappropriate use of antibiotics to treat viral infections, which do not respond to these drugs. To reduce the risk of AMR, it is important to be able to differentiate between bacterial and viral illnesses. One promising approach to this is the use of volatile organic compounds (VOCs) as biomarkers for bacterial and viral infections.

VOCs are small, volatile molecules that are produced by living organisms, including bacteria and viruses. They are highly specific to the organism that produces them and can be used to identify and track the presence of certain pathogens.

There have been several studies that have investigated the use of VOCs as biomarkers for bacterial and viral infections. One study, published in the journal Analytical Chemistry, used a combination of GC-MS and machine learning algorithms to analyze the breath of patients with bacterial and viral infections. The study found that the levels of certain VOCs, including acetone, isoprene, and 2-propanol, were significantly different between patients with bacterial and viral infections.

Another study, published in the journal PLOS ONE, used a similar approach to investigate the use of VOCs as biomarkers for bacterial and viral infections. The study used a portable device to analyze the breath of patients with bacterial and viral infections and found that the device could differentiate between the two types of infections with an accuracy of 80%.

A recent study, published in the journal Nature Communications, used a breath-sampling device to analyze the breath of patients with bacterial and viral infections. The study found that the device could differentiate between the two types of infections with an accuracy of 88% and could distinguish the VOCs patterns of common bacterial and viral infections, and could potentially reduce the unnecessary use of antibiotics.

Overall, the evidence suggests that VOCs may be useful as biomarkers for differentiating between bacterial and viral infections. The studies discussed above demonstrate that certain VOCs can be used to identify and track the presence of bacterial and viral pathogens, and that these VOCs can be identified and quantified using portable devices and machine learning algorithms. While more research is needed to confirm the utility of VOCs as biomarkers for differentiating between bacterial and viral infections, the results of these studies are promising and suggest that VOCs may be a valuable tool in reducing the risk of antimicrobial resistance.

In conclusion, using VOCs as biomarkers for differentiating between bacterial and viral infections is a promising approach to reducing the risk of antimicrobial resistance. The studies discussed in this blog support this, showing that certain VOCs can be used to identify and track the presence of bacterial and viral pathogens, and that these VOCs can be identified and quantified using portable devices and machine learning algorithms. However, more research is needed to confirm the utility.